The prelude is just some thoughts about a couple of principles.
First: the simplest thing that could possibly work. A phrase often quoted and often misapplied. This is common knowledge, and many clarify things by interpreting what "possibly work" means. I won't. I'd just like to rephrase it as "the simpler thing that actually works". It's useful since it both hints that there can be more complex/complicated things (see #3 and #4 in The Zen of Python) that don't actually work (for some arbitrary meaning of "work", admittedly), and (obviously) that there are simpler things that don't work at all (less or more simple than the one that works — this is the heart of the problem). I feel this phrasing avoids the confusion the original one often causes (it just seemed to be a simpler way of saying it that still works..). So, to repeat: just say "the simpler thing that actually works". It works.
Second: just a recap of an old joke of mine regarding the principle of DRY. I very much do prefer if programming practise adheres to that one. There's too much code that suffers from MOIST. Still, I advice you to avoid to DRY until SHRIVELLED. (Those sure are acronyms. Please do hover.) This is related to the first principle above, and I mainly mean that some practises, such as heavy use of metaprogramming, simply performs too much reduction to make the intent clear even to the appropriately trained eye. Mileage will vary, but as many others have already advised: don't be too clever. It will bite others, and you as well. (Ok; honestly, my main intent was probably just to make a pun out of a perfectly sane advice.)
I will probably repeat this.
[Side note: It's funny. Just this last week I've noticed I habitually misspell "intent" as "indent". I had to correct myself about three times while writing this. Obviously my prolonged use of Python has caused these two distinct words to conflate in my mind. I never indented that.]